Biological reactions for DNA replication, transcription, and translation are important for gene expression. We have shown that the non-canonical structures such as triplexes and G-quadruplexes play important roles in these biological reactions. Therefore, we are investigating the function of the non-canonical structures during the process of gene expression.
Reference
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H. Tateishi-Karimata, N. Isono, and N. Sugimoto
New insights into transcription fidelity: thermal stability of non-canonical structures in template DNA regulates transcriptional arrest, pause, and slippage.
PLoS One, 9, e9058 (2014) -
S. Pramanik, H. Tateishi-Karimata, and N. Sugimoto
Organelle-mimicking liposome dissociates G-quadruplexes and facilitates transcription
Nucleic Acids Res., 42, 12949-12959 (2014) -
T. Endoh, Y. Kawasaki, and N. Sugimoto
Stability of RNA quadruplex in open reading frame determines proteolysis of human estrogen receptor α
Nucleic Acids Res., 41, 6222-6231 (2013) -
T. Endoh, Y. Kawasaki, and N. Sugimoto
Suppression of gene expression by G-quadruplexes in open reading frames depends on G-quadruplex stability
Angew. Chem. Int. Ed., 52, 5522-5526 (2013) -
T. Endoh, Y. Kawasaki, and N. Sugimoto
Translational halt during elongation caused by G-quadruplex formed by mRNA
Methods, 64, 73-78 (2013)
Reviews and books
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N. Sugimoto
Regulation of Transcription and Translation by Quadruplex Structure of Nucleic Acids and Its Stabilizers
Bull. Jpn. Soc. Coord. Chem., 65, 23-29 (2015) [Award Accounts] -
S. Nakano, D. Miyoshi, and N. Sugimoto
Effects of molecular crowding on the structures, interactions, and functions of nucleic acids
Chem. Rev., 12, 114(5), 2733-2758 (2014) -
N. Sugimoto
Effect of ionic liquid and liposomes on the structure, stability, and function of nucleic acids
Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications (Springer), Mar 28, 57-74 (2014)