Recent investigations have gradually revealed that higher-order structures of template DNAs and RNAs control processes relate to gene expression, such as the replication, transcription, and translation reactions. We are developing artificial molecules that induce characteristic higher-order structures by interacting with DNA and mRNA, with the goal of achieving the artificial regulation of gene expression. In particular, small ligands, proteins, and nucleic acids, as representative biomolecules, can be modified and converted purposefully for the regulation of gene expression in a cell.
Reference
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T. Endoh, D. Hnedzko, E. Rozners, and N. Sugimoto
Nucleobase-modified PNA suppresses translation by forming a triple helix with a hairpin structure in mRNA in vitro and in cells
Angew. Chem. Int. Ed., 55, 899-903 (2016) [Selected as a Front Cover] -
A. B. Rode, T. Endoh, and N. Sugimoto
Tuning riboswitch-mediated gene regulation by rational control of aptamer ligand binding properties
Angew. Chem. Int. Ed., 54, 905-909 (2015) -
T. Endoh and N. Sugimoto
Unusual −1 ribosomal frameshift caused by stable RNA G-quadruplex in open reading frame
Anal. Chem., 85, 11435–11439 (2013)
Reviews and books
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H. Yaku, T. Murashima, D. Miyoshi, and N. Sugimoto
Specific binding of anionic porphyrin and phthalocyanine to the G-quadruplex with a variety of in vitro and in vivo applications
Molecules, 17, 10586-10613 (2012) -
H. Yaku, T. Fujimoto, T. Murashima, D. Miyoshi, and N. Sugimoto
Phthalocyanines: a new class of G-quadruplex-ligands with many potential applications
Chem. Commun., 48, 6203-6216 (2012) [Selected as a Front Cover]