The canonical structure of nucleic acids is a duplex; however, nucleic acids also form non-canonical structures such as triplexes and G-quadruplexes. We have shown that non-canonical structures are drastically stabilized in response to changes of the surrounding conditions, inducing mutations, to influence biological reactions such as transcription and translation. Therefore, we consider that the formation of non-canonical structures should play important roles in gene regulation in response to the molecular environments in cells.
Reference
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T. Fujii and N. Sugimoto
Loop nucleotides impact the stability of intrastrand i-motif structures at neutral pH
Phys. Chem. Chem. Phys., 17, 16719-16722（2015） -
H. Tateishi-Karimata, M. Nakano, S. Pramanik, S. Tanaka, and N. Sugimoto
i-motifs are more stable than G-quadruplexes in a hydrated ionic liquid
Chem. Commun., 51, 6909-6912 (2015) [Selected as an Inside Cover] -
H. Tateishi-karimata, M. Nakano, and N. Sugimoto
Comparable stability of Hoogsteen and Watson–Crick base pairs in ionic liquid choline dihydrogen phosphate.
Sci Rep. 4, 3593 (2014) -
H. Tateishi-Karimata, S. Pramanik, S. Nakano, D. Miyoshi, and N. Sugimoto
Dangling ends perturb the stability of RNA duplex responsive to surrounding condition
ChemMedChem, 9, 2150-2155 (2014) [Selected as an Inside Cover] -
M. Nakano, H. Tateishi-Karimata, S. Tanaka, and N. Sugimoto,
Choline ion interactions with DNA atoms explain unique stabilization of A-T base pairs in DNA duplexes: A microscopic view
J. Phys. Chem. B, 118, 379-389 (2014) [Selected as a Front Cover] -
H. Tateishi-Karimata and N. Sugimoto
A–T base pairs are more stable than G–C base pairs in a hydrated ionic liquid
Angew. Chem. Int. Ed., 51, 1416-1419 (2012) [Selected as Back Cover and Hot Topics in Wiley] -
V. Kumar, T. Endoh, K. Murakami, and N. Sugimoto
Dehydration from conserved stem regions is fundamental for ligand-dependent conformational transition of the adenine-specific riboswitch
Chem. Commun., 48, 9693-9695 (2012) [Selected as a Front Cover]
Reviews and books
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S. Nakano, D. Miyoshi, and N. Sugimoto
Effects of molecular crowding on the structures, interactions, and functions of nucleic acids
Chem. Rev., 12, 114(5), 2733-2758 (2014) -
H. Tateishi-Karimata and N. Sugimoto
Structure, stability and behavior of nucleic acids in ionic liquids
Nucleic Acids Res., 42, 8831-8844 (2014) -
N. Sugimoto
Effect of ionic liquid and liposomes on the structure, stability, and function of nucleic acids
Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications (Springer), Mar 28, 57-74 (2014) -
H. Tateishi-Karimata, S. Nakano, and N. Sugimoto
Quantitative analyses of nucleic acid stability under the molecular crowding condition induced by cosolutes
Curr. Protoc. Nucleic Acid Chem.,7, Unit 7.19 (2013）